IUBMB Enzyme Nomenclature


Accepted name: hydroxyacid-oxoacid transhydrogenase

Reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate

Other name(s): transhydrogenase, hydroxy acid-oxo acid

Systematic name: (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase

Comments: 4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 117698-31-4


1. Kaufman, E.E., Nelson, T., Fales, H.M. and Levin, D.M. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. J. Biol. Chem. 263 (1988) 16872-16879. [PMID: 3182820]

[EC created 1992]

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