IUBMB Enzyme Nomenclature


Accepted name: (R)-pantolactone dehydrogenase (flavin)

Reaction: (R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor

Other name(s): 2-dehydropantolactone reductase (flavin); 2-dehydropantoyl-lactone reductase (flavin); (R)-pantoyllactone dehydrogenase (flavin)

Systematic name: (R)-pantolactone:acceptor oxidoreductase (flavin-containing)

Comments: high specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 140879-14-7


1. Kataoka, M., Shimizu, S. and Yamada, H. Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides. Eur. J. Biochem. 204 (1992) 799-806. [PMID: 1541293]

[EC created 1999]

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