IUBMB Enzyme Nomenclature


Accepted name: L-sorbose 1-dehydrogenase

Reaction: L-sorbose + acceptor = 1-dehydro-L-sorbose + reduced acceptor

Glossary: 1-dehydro-L-sorbose = L-sorbosone = 2-dehydro-L-gulose

Other name(s): SDH (ambiguous)

Systematic name: L-sorbose:acceptor 1-oxidoreductase

Comments: The product, L-sorbosone, is an intermediate in bacterial 2-keto-L-gulonic-acid formation. The activity of this membrane-bound enzyme is stimulated by Fe(III) or Co2+ but is inhibited by Cu2+. The enzyme is highly specific for L-sorbose as other sugars, such as glucose, mannitol and sorbitol, are not substrates. Phenazine methosulfate and DCIP can act as artificial acceptors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Sugisawa, T., Hoshino, T., Nomura, S. and Fujiwara, A. Isolation and characterization of membrane-bound L-sorbose dehydrogenase from Gluconobacter melanogenus UV10. Agric. Biol. Chem. 55 (1991) 363-370.

[EC created 2008]

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