IUBMB Enzyme Nomenclature


Accepted name: D-lactate dehydrogenase (acceptor)

Reaction: (R)-lactate + acceptor = pyruvate + reduced acceptor

Other name(s): D-2-hydroxy acid dehydrogenase; D-2-hydroxy-acid dehydrogenase; (R)-2-hydroxy-acid:acceptor 2-oxidoreductase

Systematic name: (R)-lactate:acceptor 2-oxidoreductase

Comments: The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-83-5


1. Reed, D.W. and Hartzell, P.L. The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn2+ flavoprotein. J. Bacteriol. 181 (1999) 7580-7587. [PMID: 10601217]

[EC created 1965, modified 2013]

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