IUBMB Enzyme Nomenclature


Accepted name: lactate—malate transhydrogenase

Reaction: (S)-lactate + oxaloacetate = pyruvate + malate

Other name(s): malate-lactate transhydrogenase

Systematic name: (S)-lactate:oxaloacetate oxidoreductase

Comments: Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 9077-15-0


1. Allen, S.H.G. The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus. J. Biol. Chem. 241 (1966) 5266-5275. [PMID: 4289051]

2. Allen, S.H.G. and Patil, J.R. Studies on the structure and mechanism of action of the malate-lactate transhydrogenase. J. Biol. Chem. 247 (1972) 909-916. [PMID: 4333516]

[EC created 1972]

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