Reaction: 4 (R)-torosachrysone + O2 = 2 phlegmacin + 2 H2O
Other name(s): phlC (gene name)
Systematic name: (R)-torosachrysone:oxygen oxidoreductase (phlegmacin-forming)
Comments: The enzyme, characterized from the ascomycete fungus Talaromyces sp. F08Z-0631, catalyses the regioselective coupling of two molecules of the phenolic compound (R)-torosachrysone at the corresponding C7 and C10' positions, forming the 7,1'-coupled dimeric product (phlegmacin). The reaction requires the participation of a fasciclin partner protein. cf. EC 1.11.2.7, torosachrysone 7,1'-coupling peroxygenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Zhao, Q., Zhuang, Z., Liu, T., Yang, Q., He, Q.L., Liu, W. and Lin, G.Q. Unsymmetrically regioselective homodimerization depends on the subcellular colocalization of laccase/fasciclin protein in the biosynthesis of phlegmacins. ACS Chem. Biol. 17 (2022) 791-796. [PMID: 35274920]
2. Platz, L., Lohr, N.A., Girkens, M.P., Eisen, F., Braun, K., Fessner, N., Bar, C., Huttel, W., Hoffmeister, D. and Muller, M. Regioselective oxidative phenol coupling by a mushroom unspecific peroxygenase. Angew. Chem. Int. Ed. Engl. 63 (2024) e202407425. [PMID: 38963262]