Reaction: L-tryptophan + H2O2 = 5-hydroxy-L-tryptophan + H2O
Other name(s): luz15 (gene name); bacterial tryptophan 5-hydroxylase
Systematic name: L-tryptophan:hydrogen-peroxide 5-oxidoreductase
Comments: The enzyme from the bacterium Actinomadura luzonensis is involved in the biosynthesis of the antitumour and antiviral depsipeptide luzopeptin A. Contains a heme b cofactor. The enzyme can use O2 (and ascorbate) instead of H2O2, but the reaction with H2O2 is at least two orders of magnitude faster. cf. EC 1.14.16.4, tryptophan 5-monooxygenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Shi, X., Zhao, G., Li, H., Zhao, Z., Li, W., Wu, M. and Du, Y.L. Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria. Nat. Chem. Biol. 19 (2023) 1415-1422. [PMID: 37653171]