IUBMB Enzyme Nomenclature


Accepted name: hydrogen dehydrogenase

Reaction: H2 + NAD+ = H+ + NADH

Other name(s): H2:NAD+ oxidoreductase; NAD-linked hydrogenase; bidirectional hydrogenase; hydrogenase

Systematic name: hydrogen:NAD+ oxidoreductase

Comments: An iron-sulfur flavoprotein (FMN or FAD). Some forms of this enzyme contain nickel.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9027-05-8


1. Bone, D.H., Bernstein, S. and Vishniac, W. Purification and some properties of different forms of hydrogen dehydrogenase. Biochim. Biophys. Acta 67 (1963) 581-588.

2. Schneider, K. and Schlegel, H.G. Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16. Biochim. Biophys. Acta 452 (1976) 66-80. [PMID: 186126]

[EC created 1972, modified 2002]

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