IUBMB Enzyme Nomenclature


Accepted name: 7,8-dihydroxykynurenate 8,8a-dioxygenase

Reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate

Other name(s): 7,8-dihydroxykynurenate oxygenase; 7,8-dihydroxykynurenate 8,8α-dioxygenase; 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)

Systematic name: 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (ring-opening)

Comments: Requires Fe2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-58-7


1. Kuno, S., Tashiro, M., Taniuchi, H., Horibata, K., Hayaishi, O., Seno, S., Tokuyama, T. and Sakan, T. Enzymatic degradation of kynurenic acid. Fed. Proc. 20 (1961) 3.

[EC created 1965 as EC, transferred 1972 to EC]

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