IUBMB Enzyme Nomenclature


Accepted name: peptide-tryptophan 2,3-dioxygenase

Reaction: [protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine

Glossary: N-formyl-L-kynurenine = (2S)-2-amino-4-[2-(formamido)phenyl]-4-oxobutanoic acid

Other name(s): pyrrolooxygenase; peptidyltryptophan 2,3-dioxygenase; tryptophan pyrrolooxygenase; [protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

Systematic name: [protein]-L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)

Comments: Also acts on tryptophan.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37256-64-7


1. Frydman, R.B., Tomaro, M.L. and Frydman, B. Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides. Biochim. Biophys. Acta 284 (1972) 80-89. [PMID: 4403729]

2. Camoretti-Mercado, B. and Frydman, R.B. Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins. Eur. J. Biochem. 156 (1986) 317-325. [PMID: 3699018]

[EC created 1972, modified 2011]

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