IUBMB Enzyme Nomenclature


Accepted name: arachidonate 15-lipoxygenase

Reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Other name(s): 15-lipoxygenase; linoleic acid ω6-lipoxygenase; ω6 lipoxygenase

Systematic name: arachidonate:oxygen 15-oxidoreductase

Comments: The product is rapidly reduced to the corresponding 15S-hydroxy compound.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 82249-77-2


1. Bryant, R.W., Bailey, J.M., Schewqe, T. and Rapoport, S.M. Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. J. Biol. Chem. 257 (1982) 6050-6055. [PMID: 6804460]

2. Narumiya, S. and Salmon, J.A. Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Methods Enzymol. 86 (1982) 45-48. [PMID: 6813644]

3. Oliw, E.H. and Sprecher, H. Metabolism of polyunsaturated fatty acids by an (n-6)-lipoxygenase associated with human ejaculates. Biochim. Biophys. Acta 1002 (1989) 283-291. [PMID: 2496760]

4. Shibata, D., Steczko, J., Dixon, F.E., Hermodson, M., Yasdanparast, R. and Axelrod, B. Primary structure of soybean lipoxygenase-1. J. Biol. Chem. 262 (1987) 10080-10085. [PMID: 3112136]

[EC created 1984]

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