IUBMB Enzyme Nomenclature


Accepted name: 1-hydroxy-2-naphthoate 1,2-dioxygenase

Reaction: 1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate

For diagram of reaction click here

Other name(s): 1-hydroxy-2-naphthoate dioxygenase; 1-hydroxy-2-naphthoate-degrading enzyme; 1-hydroxy-2-naphthoic acid dioxygenase; 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)

Systematic name: 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (ring-opening)

Comments: Requires Fe2+. Involved, with EC 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase, in the metabolism of phenanthrene in bacteria.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number: 85941-64-6


1. Barnsley, E.A. Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate. J. Bacteriol. 154 (1983) 113-117. [PMID: 6833175]

[EC created 1989]

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