IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxymandelate synthase

Reaction: 4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2

For diagram of reaction click here.

Glossary: (S)-4-hydroxymandelate = (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate

Other name(s): 4-hydroxyphenylpyruvate dioxygenase II

Systematic name: (S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

Comments: Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 280566-04-3


1. Hubbard, B.K., Thomas, M.G. and Walsh, C.T. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chem. Biol. 7 (2000) 931-942. [PMID: 11137816]

2. Choroba, O.W., Williams, D.H. and Spencer, J.B. Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine. J. Am. Chem. Soc. 122 (2000) 5389-5390.

[EC created 2001]

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