IUBMB Enzyme Nomenclature


Accepted name: homogentisate 1,2-dioxygenase

Reaction: homogentisate + O2 = 4-maleylacetoacetate

For diagram of reaction click here.

Other name(s): homogentisicase; homogentisate oxygenase; homogentisate dioxygenase; homogentisate oxidase; homogentisic acid oxidase; homogentisic acid oxygenase; homogentisic oxygenase

Systematic name: homogentisate:oxygen 1,2-oxidoreductase (decyclizing)

Comments: Requires Fe2+.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-49-6


1. Adachi, K., Iwayama, Y., Tanioka, H. and Takeda, Y. Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens. Biochim. Biophys. Acta 118 (1966) 88-97. [PMID: 5954067]

2. Crandall, D.I. and Halikis, D.N. Homogentisic acid oxidase. I. Distribution in animal tissues and relation to tyrosine metabolism in rat kidney. J. Biol. Chem. 208 (1954) 629-638.

3. Hayaishi, O. Direct oxygenation by O2, oxygenases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.

4. Kita, H., Kamimoto, M., Senoh, S., Adachi, T. and Takeda, Y. Cystallization and some properties of 3,4-dihydroxyphenylacetate-2,3-oxygenase. Biochem. Biophys. Res. Commun. 18 (1965) 66-70.

5. Knox, W.E. and Edwards, S.W. Homogentisate oxidase of liver. J. Biol. Chem. 216 (1955) 479-487.

6. Ravdin, R.G. and Crandall, D.I. The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid. J. Biol. Chem. 189 (1951) 137-149.

[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC]

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