IUBMB Enzyme Nomenclature


Accepted name: linoleate 10R-lipoxygenase

Reaction: linoleate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate

Glossary: linoleate = (9Z,12Z)-octadeca-9,12-dienoate

Other name(s): 10R-DOX; (10R)-dioxygenase; 10R-dioxygenase

Systematic name: linoleate:oxygen (10R)-oxidoreductase

Comments: The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Garscha, U. and Oliw, E.H. Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity. J. Biol. Chem. 284 (2009) 13755-13765. [PMID: 19289462]

2. Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. Biochim. Biophys. Acta 1801 (2010) 503-507. [PMID: 20045744]

[EC created 2011]

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