IUBMB Enzyme Nomenclature


Accepted name: all-trans-10'-apo-β-carotenal 13,14-cleaving dioxygenase

Reaction: all-trans-10'-apo-β-carotenal + O2 = 13-apo-β-carotenone + (2E,4E,6E)-4-methylocta-2,4,6-trienedial

For diagram of reaction click here.

Other name(s): CCD8 (gene name); MAX4 (gene name); NCED8 (gene name); all-trans-10'-apo-β-carotenal:O2 oxidoreductase (13,14-cleaving)

Systematic name: all-trans-10'-apo-β-carotenal:oxygen oxidoreductase (13,14-cleaving)

Comments: Requires Fe2+. The enzyme from the plant Arabidopsis thaliana also catalyses EC, carlactone synthase, 10-fold faster.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Schwartz, S.H., Qin, X. and Loewen, M.C. The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching. J. Biol. Chem. 279 (2004) 46940-46945. [PMID: 15342640]

[EC created 2012]

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