IUBMB Enzyme Nomenclature


Accepted name: carotenoid-9',10'-cleaving dioxygenase

Reaction: all-trans-β-carotene + O2 = all-trans-10'-apo-β-carotenal + β-ionone

For diagram of reaction click here.

Other name(s): BCO2 (gene name); β-carotene 9',10'-monooxygenase (misleading); all-trans-β-carotene:O2 oxidoreductase (9',10'-cleaving)

Systematic name: all-trans-β-carotene:oxygen oxidoreductase (9',10'-cleaving)

Comments: Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kiefer, C., Hessel, S., Lampert, J.M., Vogt, K., Lederer, M.O., Breithaupt, D.E. and von Lintig, J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J. Biol. Chem. 276 (2001) 14110-14116. [PMID: 11278918]

2. Lindqvist, A., He, Y.G. and Andersson, S. Cell type-specific expression of β-carotene 9',10'-monooxygenase in human tissues. J. Histochem. Cytochem. 53 (2005) 1403-1412. [PMID: 15983114]

[EC created 2012]

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