IUBMB Enzyme Nomenclature


Accepted name: methylphosphonate synthase

Reaction: 2-hydroxyethylphosphonate + O2 = methylphosphonate + HCO3-

For diagram of reaction click here.

Other name(s): mpnS (gene name); 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (methylphosphonate forming)

Systematic name: 2-hydroxyethylphosphonate:oxygen 1,2-oxidoreductase (methylphosphonate forming)

Comments: Isolated from the marine archaeon Nitrosopumilus maritimus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Metcalf, W.W., Griffin, B.M., Cicchillo, R.M., Gao, J., Janga, S.C., Cooke, H.A., Circello, B.T., Evans, B.S., Martens-Habbena, W., Stahl, D.A. and van der Donk, W.A. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science 337 (2012) 1104-1107. [PMID: 22936780]

[EC created 2012]

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