IUBMB Enzyme Nomenclature


Accepted name: protocatechuate 4,5-dioxygenase

Reaction: 3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde

For diagram of reaction click here

Glossary: 3,4-dihydroxybenzoate = protocatechuate

Other name(s): protocatechuate 4,5-oxygenase; protocatechuic 4,5-dioxygenase; protocatechuic 4,5-oxygenase; protocatechuate:oxygen 4,5-oxidoreductase (decyclizing); protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)

Systematic name: 3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)

Comments: Requires Fe2+.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-56-5


1. Trippett, S., Dagley, S. and Stopher, D.A. The bacterial oxidation of nicotinic acid Biochem. J. 76 (1960) 9P.

[EC created 1965 as EC, transferred 1972 to EC]

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