Reaction: 5-aminosalicylate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
Glossary: 5-aminosalicylate = 5-amino-2-hydroxybenzoate
Other name(s): mabB (gene name)
Systematic name: 5-aminosalicylate:oxygen 1,2-oxidoreductase (ring-opening)
Comments: Requires iron(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Stolz, A., Nortemann, B. and Knackmuss, H.J. Bacterial metabolism of 5-aminosalicylic acid. Initial ring cleavage. Biochem. J. 282 (1992) 675-680. [PMID: 1554350]
2. Yu, H., Zhao, S. and Guo, L. Novel gene encoding 5-aminosalicylate 1,2-dioxygenase from Comamonas sp. strain QT12 and catalytic properties of the purified enzyme. J. Bacteriol. 200 (2018) . [PMID: 29038259]