IUBMB Enzyme Nomenclature


Accepted name: hydroxymethylphosphonate dioxygenase

Reaction: (hydroxymethyl)phosphonate + O2 = formate + phosphate

Other name(s): phnZ1 (gene name)

Systematic name: hydroxymethylphosphonate:oxygen 1-oxidoreductase (formate-forming)

Comments: Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Gama, S.R., Vogt, M., Kalina, T., Hupp, K., Hammerschmidt, F., Pallitsch, K. and Zechel, D.L. An oxidative pathway for microbial utilization of methylphosphonic acid as a phosphate source. ACS Chem. Biol. 14 (2019) 735-741. [PMID: 30810303]

[EC created 2019]

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