Reaction: questin hydroquinone + O2 = demethylsulochrin
Glossary: questin hydroquinone = 1,6,10-trihydroxy-8-methoxy-3-methyl-10H-anthracen-9-one
demethylsulochrin = 2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate
Other name(s): gedK (gene name)
Systematic name: questin hydroquinone:oxygen 10,4a-oxidoreductase (ring-opening)
Comments: The enzyme, characterized from the fungus Aspergillus terreus, cleaves the C-10—C-4a bond of the anthraquinone ring during the biosynthesis of (+)-geodin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Qi, F., Zhang, W., Xue, Y., Geng, C., Huang, X., Sun, J. and Lu, X. Bienzyme-catalytic and dioxygenation-mediated anthraquinone ring opening. J. Am. Chem. Soc. 143 (2021) 16326-16331. [PMID: 34586791]