IUBMB Enzyme Nomenclature


Accepted name: tetracenomycin-F1 monooxygenase

Reaction: tetracenomycin F1 + O2 = tetracenomycin D3 + H2O

For diagram of reaction click here.

Glossary: tetracenomycin D3 = 3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxonaphthacene-2-carboxylic acid
tetracenomycin F1 = 3,8,10,12-tetrahydroxy-1-methyl-11-oxo-6,11-dihydro-2-tetracenecarboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-11-oxonaphthacene-2-carboxylic acid

Other name(s): tcmH (gene name)

Systematic name: tetracenomycin-F1:oxygen C5-monooxygenase

Comments: The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Shen, B. and Hutchinson, C.R. Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Biochemistry 32 (1993) 6656-6663. [PMID: 8329392]

[EC created 2013]

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