Reaction: myo-inositol + O2 = D-glucuronate + H2O
For diagram click here.
Other name(s): meso-inositol oxygenase; myo-inositol oxygenase; MOO
Systematic name: myo-inositol:oxygen oxidoreductase
Comments: An iron protein. Formerly EC 1.13.1.11 and EC 1.99.2.6.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-59-8
References:
1. Charalampous, F.C. Biochemical studies on inositol. V. Purification and properties of the enzyme that cleaves inositol to D-glucuronic acid. J. Biol. Chem. 234 (1959) 220-227.
2. Reddy, C.C., Swan, J.S. and Hamilton, G.A. myo-Inositol oxygenase from hog kidney. I. Purification and characterization of the oxygenase and of an enzyme complex containing the oxygenase and D-glucuronate reductase. J. Biol. Chem. 256 (1981) 8510-8518. [PMID: 7263666]
3. Arner, R.J., Prabhu, K.S., Thompson, J.T., Hildenbrandt, G.R., Liken, A.D. and Reddy, C.C. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. Biochem. J. 360 (2001) 313-320. [PMID: 11716759]