IUBMB Enzyme Nomenclature


Accepted name: tryptophan 2'-dioxygenase

Reaction: L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3

Other name(s): indole-3-alkane α-hydroxylase; tryptophan side-chain α,β-oxidase; tryptophan side chain oxidase II; tryptophan side-chain oxidase; TSO; indolyl-3-alkane α-hydroxylase; tryptophan side chain oxidase type I; TSO I ; TSO II; tryptophan side chain oxidase

Systematic name: L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)

Comments: A hemoprotein. Acts on a number of indolyl-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 64295-81-4


1. Roberts, J. and Rosenfeld, H.J. Isolation, crystallization, and properties of indolyl-3-alkane α-hydroxylase. A novel tryptophan-metabolizing enzyme. J. Biol. Chem. 252 (1977) 2640-2647. [PMID: 15994]

2. Takai, K., Ushiro, H., Noda, Y., Narumiya, S., Tokuyama, T. and Hayaishi, O. Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives. J. Biol. Chem. 252 (1977) 2648-2656. [PMID: 15995]

[EC created 1984]

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