IUBMB Enzyme Nomenclature


Accepted name: hyoscyamine (6S)-dioxygenase

Reaction: L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2

For diagram of reaction, click here.

Other name(s): hyoscyamine 6β-hydroxylase; hyoscyamine 6β-dioxygenase; hyoscyamine 6-hydroxylase

Systematic name: L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating]

Comments: Requires Fe2+ and ascorbate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 103865-33-4


1. Hashimoto, T. and Yamada, Y. Hyoscyamine 6β-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, in alkaloid-producing root cultures. Plant Physiol. 81 (1986) 619-625.

[EC created 1989]

Return to EC 1.14.11 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page