IUBMB Enzyme Nomenclature


Accepted name: deacetoxyvindoline 4-hydroxylase

Reaction: deacetoxyvindoline + 2-oxoglutarate + O2 = deacetylvindoline + succinate + CO2

For reaction pathway click here.

Other name(s): desacetoxyvindoline 4-hydroxylase; desacetyoxyvindoline-17-hydroxylase; D17H; desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4β-hydroxylating)

Systematic name: deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4β-hydroxylating)

Comments: Requires Fe2+ and ascorbate. Also acts on 3-hydroxy-16-methoxy-2,3-dihydrotabersonine and to a lesser extent on 16-methoxy-2,3-dihydrotabersonine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 132084-83-4


1. De Carolis, E., Chan, F., Balsevich, J. and De Luca, V. Isolation and characterization of a 2-oxoglutarate dependent dioxygenase involved in the 2nd-to-last step in vindoline biosynthesis Plant Physiol. 94 (1990) 1323-1329.

2. De Carolis, E. and De Luca, V. Purification, characterization, and kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus. J. Biol. Chem. 268 (1993) 5504-5511. [PMID: 8449913]

3. Vazquez-Flota, F.A. and De Luca, V. Developmental and light regulation of desacetoxyvindoline 4-hydroxylase in Catharanthus roseus (L.) G. Don. Evidence of a multilevel regulatory mechanism. Plant Physiol. 117 (1998) 1351-1361. [PMID: 9701591]

[EC created 2002, modified 2005]

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