IUBMB Enzyme Nomenclature


Accepted name: codeine 3-O-demethylase

Reaction: codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2

Other name(s): codeine O-demethylase; CODM

Systematic name: codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating)

Comments: Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hagel, J.M. and Facchini, P.J. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat. Chem. Biol. 6 (2010) 273-275. [PMID: 20228795]

[EC created 2010]

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