IUBMB Enzyme Nomenclature


Accepted name: xanthine dioxygenase

Reaction: xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2

For diagram click here.

Other name(s): XanA; α-ketoglutarate-dependent xanthine hydroxylase

Systematic name: xanthine,2-oxoglutarate:oxygen oxidoreductase

Comments: Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Cultrone, A., Scazzocchio, C., Rochet, M., Montero-Moran, G., Drevet, C. and Fernandez-Martin, R. Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via α-ketoglutarate-dependent dioxygenases. Mol. Microbiol. 57 (2005) 276-290. [PMID: 15948966]

2. Montero-Moran, G.M., Li, M., Rendon-Huerta, E., Jourdan, F., Lowe, D.J., Stumpff-Kane, A.W., Feig, M., Scazzocchio, C. and Hausinger, R.P. Purification and characterization of the FeII- and α-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans. Biochemistry 46 (2007) 5293-5304. [PMID: 17429948]

3. Li, M., Muller, T.A., Fraser, B.A. and Hausinger, R.P. Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans. Arch. Biochem. Biophys. 470 (2008) 44-53. [PMID: 18036331]

[EC created 2015]

Return to EC 1.14.11 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page