IUBMB Enzyme Nomenclature


Accepted name: validamycin A dioxygenase

Reaction: validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2

For diagram of reaction click here.

Glossary: validamycin A = (1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl β-D-glucopyranoside
validamycin B = (1R,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl β-D-glucopyranoside

Other name(s): vldW (gene name)

Systematic name: validamycin-A,2-oxoglutarate:oxygen oxidoreductase (6'-hydroxylating)

Comments: The enzyme was characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus. Requires Fe2+.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Almabruk, K.H., Asamizu, S., Chang, A., Varghese, S.G. and Mahmud, T. The α-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B. Chembiochem 13 (2012) 2209-2211. [PMID: 22961651]

[EC created 2016]

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