IUBMB Enzyme Nomenclature


Accepted name: scopoletin 8-hydroxylase

Reaction: scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2

Glossary: fraxetin = 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
scopoletin = 7-hydroxy-6-methoxy-2H-chromen-2-one

Other name(s): S8H (gene name)

Systematic name: scopoletin,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)

Comments: Requires iron(II) and ascorbate. A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Siwinska, J., Siatkowska, K., Olry, A., Grosjean, J., Hehn, A., Bourgaud, F., Meharg, A.A., Carey, M., Lojkowska, E. and Ihnatowicz, A. Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis. J. Exp. Bot. 69 (2018) 1735-1748. [PMID: 29361149]

2. Rajniak, J., Giehl, R.FH., Chang, E., Murgia, I., von Wiren, N. and Sattely, E.S. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Nat. Chem. Biol. 14 (2018) 442-450. [PMID: 29581584]

[EC created 2018]

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