IUBMB Enzyme Nomenclature


Accepted name: [2-(trimethylamino)ethyl]phosphonate dioxygenase

Reaction: [2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2

Other name(s): tmpA (gene name)

Systematic name: [2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)

Comments: Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Rajakovich, L.J., Pandelia, M.E., Mitchell, A.J., Chang, W.C., Zhang, B., Boal, A.K., Krebs, C. and Bollinger, J.M., Jr. A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases. Biochemistry 58 (2019) 1627-1647. [PMID: 30789718]

[EC created 2020]

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