IUBMB Enzyme Nomenclature


Accepted name: L-isoleucine 31-dioxygenase

Reaction: L-isoleucine + 2-oxoglutarate + O2 = 31-hydroxy-L-isoleucine + succinate + CO2

Other name(s): hilA (gene name); L-isoleucine 4'-dioxygenase (incorrect)

Systematic name: L-isoleucine, 2-oxoglutarate:oxygen oxidoreductase (31-hydroxylating)

Comments: Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Smirnov, S.V., Sokolov, P.M., Kotlyarova, V.A., Samsonova, N.N., Kodera, T., Sugiyama, M., Torii, T., Hibi, M., Shimizu, S., Yokozeki, K. and Ogawa, J. A novel L-isoleucine-4'-dioxygenase and L-isoleucine dihydroxylation cascade in Pantoea ananatis. MicrobiologyOpen 2 (2013) 471-481. [PMID: 23554367]

[EC created 2020]

Return to EC 1.14.11 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page