IUBMB Enzyme Nomenclature


Accepted name: L-glutamate 3(R)-hydroxylase

Reaction: L-glutamate + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-glutamate + succinate + CO2

Glossary: ibotenate = (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetate
muscimol = 5-(aminomethyl)-1,2-oxazol-3-ol

Other name(s): iboH (gene name)

Systematic name: L-glutamate,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating)

Comments: Requires Fe2+ and L-ascorbate. The enzyme, characterized from the basidiomycete mushroom Amanita muscaria, participates in the biosynthesis of the psychoactive compounds ibotenate and muscimol.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Muller, M. and Obermaier, S. Ibotenic acid biosynthesis in the fly agaric is initiated by glutamate hydroxylation. Angew. Chem. Int. Ed. Engl. 59 (2020) 12432-12435. [PMID: 32233056]

[EC created 2020]

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