Reaction: anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3
For diagram of reaction click here.
Other name(s): anthranilate hydroxylase; anthranilic hydroxylase; anthranilic acid hydroxylase
Systematic name: anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Comments: Requires Fe2+.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number: 9059-17-0
References:
1. Kobayashi, S. and Hayaishi, O. Anthranilic acid conversion to catechol (Pseudomonas). Methods Enzymol. 17A (1970) 505-510.
2. Taniguchi, H., Hatanaka, M., Kuno, S., Hayaishi, O., Nakajima, M. and Kurihara, N. Enzymatic formation of catechol from anthranilic acid. J. Biol. Chem. 239 (1964) 2204-2211.