IUBMB Enzyme Nomenclature


Accepted name: benzene 1,2-dioxygenase

Reaction: benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+

For diagram click here.

Other name(s): benzene hydroxylase; benzene dioxygenase

Systematic name: benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)

Comments: A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin. Requires Fe2+.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9075-66-5


1. Gibson, D.T., Koch, J.R. and Kallio, R.E. Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene. Biochemistry 7 (1968) 2653-2662. [PMID: 4298226]

[EC created 1972]

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