IUBMB Enzyme Nomenclature


Accepted name: phthalate 4,5-dioxygenase

Reaction: phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+

For diagram click here.

Other name(s): PDO ; phthalate dioxygenase

Systematic name: phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)

Comments: A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 63626-44-8


1. Batie, C.J., Lattaie, E. and Ballou, D.P. Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia. J. Biol. Chem. 262 (1987) 1510-1518. [PMID: 3805038]

[EC created 1990]

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