IUBMB Enzyme Nomenclature


Accepted name: 6-hydroxynicotinate 3-monooxygenase

Reaction: 6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2

Other name(s): NicC; 6HNA monooxygenase; HNA-3-monooxygenase

Systematic name: 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)

Comments: A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Nakano, H., Wieser, M., Hurh, B., Kawai, T., Yoshida, T., Yamane, T. and Nagasawa, T. Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5. Eur. J. Biochem. 260 (1999) 120-126. [PMID: 10091591]

2. Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. Proc. Natl. Acad. Sci. USA 105 (2008) 11329-11334. [PMID: 18678916]

[EC created 2010]

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