IUBMB Enzyme Nomenclature


Accepted name: taxoid 14β-hydroxylase

Reaction: 10β-hydroxytaxa-4(20),11-dien-5α-yl acetate + O2 + NADPH + H+ = 10β,14β-dihydroxytaxa-4(20),11-dien-5α-yl acetate + NADP+ + H2O

For diagram of reaction click here.

Systematic name: 10β-hydroxytaxa-4(20),11-dien-5α-yl-acetate,NADPH:oxygen 14-oxidoreductase

Comments: Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5α-yl acetate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R. Taxoid metabolism: taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch. Biochem. Biophys. 413 (2003) 262-270. [PMID: 12729625]

[EC created 2012]

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