IUBMB Enzyme Nomenclature


Accepted name: 5-methyl-1-naphthoate 3-hydroxylase

Reaction: 5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O

For diagram of reaction click here.

Other name(s): AziB1

Systematic name: 5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)

Comments: The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ding, W., Deng, W., Tang, M., Zhang, Q., Tang, G., Bi, Y. and Liu, W. Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. Mol. Biosyst. 6 (2010) 1071-1081. [PMID: 20485749]

[EC created 2014]

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