IUBMB Enzyme Nomenclature


Accepted name: asperlicin C monooxygenase

Reaction: asperlicin C + NAD(P)H + H+ + O2 = asperlicin E + NAD(P)+ + H2O

Other name(s): AspB

Systematic name: asperlicin C,NAD(P)H:oxygen oxidoreductase

Comments: The enzyme, characterized from the fungus Aspergillus alliaceus, contains an FAD cofactor. The enzyme inserts a hydroxyl group, leading to formation of a N-C bond that creates an additional cycle between the bicyclic indole and the tetracyclic core moieties, resulting in the heptacyclic asperlicin E.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Haynes, S.W., Gao, X., Tang, Y. and Walsh, C.T. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. J. Am. Chem. Soc. 134 (2012) 17444-17447. [PMID: 23030663]

[EC created 2016]

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