IUBMB Enzyme Nomenclature


Accepted name: dimethylamine monooxygenase

Reaction: dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O

Other name(s): dmmABC (gene names)

Systematic name: dimethylamine,NADPH:oxygen oxidoreductase (formaldehyde-forming)

Comments: The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Eady, R.R. and Large, P.J. Bacterial oxidation of dimethylamine, a new mono-oxygenase reaction. Biochem. J. 111 (1969) 37P-38P. [PMID: 4389011]

2. Eady, R.R., Jarman, T.R. and Large, P.J. Microbial oxidation of amines. Partial purification of a mixed-function secondary-amine oxidase system from Pseudomonas aminovorans that contains an enzymically active cytochrome-P-420-type haemoprotein. Biochem. J. 125 (1971) 449-459. [PMID: 4401380]

3. Alberta, J.A. and Dawson, J.H. Purification to homogeneity and initial physical characterization of secondary amine monooxygenase. J. Biol. Chem. 262 (1987) 11857-11863. [PMID: 3624236]

4. Lidbury, I., Mausz, M.A., Scanlan, D.J. and Chen, Y. Identification of dimethylamine monooxygenase in marine bacteria reveals a metabolic bottleneck in the methylated amine degradation pathway. LID - 10.1038/ismej.2017.31 [doi. ISME J. (2017) . [PMID: 28304370]

[EC created 2017]

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