Reaction: anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+
Glossary: anthraniloyl-CoA = 2-aminobenzoyl-CoA
Other name(s): anthraniloyl coenzyme A reductase; 2-aminobenzoyl-CoA monooxygenase/reductase; 2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
Systematic name: anthraniloyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
Comments: A flavoprotein (FAD). The non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexanedione.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, CAS registry number: 112692-57-6
References:
1. Buder, R. and Fuchs, G. 2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Purification and some properties of the enzyme. Eur. J. Biochem. 185 (1989) 629-635. [PMID: 2591379]
2. Buder, R., Ziegler, K., Fuchs, G., Langkau, B. and Ghisla, S. 2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction. Eur. J. Biochem. 185 (1989) 637-643. [PMID: 2591380]
3. Langkau, B., Ghisla, S., Buder, R., Ziegler, K. and Fuchs, G. 2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products. Eur. J. Biochem. 191 (1990) 365-371. [PMID: 2384085]