IUBMB Enzyme Nomenclature


Accepted name: 3-hydroxyphenylacetate 6-hydroxylase

Reaction: 3-hydroxyphenylacetate + NAD(P)H + H+ + O2 = 2,5-dihydroxyphenylacetate + NAD(P)+ + H2O

For diagram of reaction click here.

Glossary: homogentisate = 2,5-dihydroxyphenylacetate

Other name(s): 3-hydroxyphenylacetate 6-monooxygenase

Systematic name: 3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)

Comments: 3-hydroxyphenylacetate 6-hydroxylase from Flavobacterium sp. is highly specific for 3-hydroxyphenylacetate and uses NADH and NADPH as electron donors with similar efficiency.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114705-01-0


1. van Berkel, W.H.J. and van den Tweel, W.J.J. Purification and characterisation of 3-hydroxyphenylacetate 6-hydroxylase: a novel FAD-dependent monooxygenase from a Flavobacterium sp. Eur. J. Biochem. 201 (1991) 585-592. [PMID: 1935954]

[EC created 1999]

Return to EC 1.14.13 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page