IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxycyclohexanone 2-monooxygenase

Reaction: 2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O

Systematic name: 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)

Comment: the product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62628-31-3


1. Davey, J.F. and Trudgill, P.W. The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species. Eur. J. Biochem. 74 (1977) 115-127. [PMID: 856571]

[EC created 1978 as EC, transferred 1999 to EC]

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