IUBMB Enzyme Nomenclature


Accepted name: vanillate monooxygenase

Reaction: vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde

For diagram of reaction click here

Glossary entries: vanillate = 4-hydroxy-3-methoxybenzoate

Other name(s): 4-hydroxy-3-methoxybenzoate demethylase; vanillate demethylase

Systematic name: vanillate:oxygen oxidoreductase (demethylating)

Comments: Forms part of the vanillin degradation pathway in Arthrobacter sp.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 39307-11-4


1. Brunel, F. and Davison, J. Cloning and sequencing of Pseudomonas genes encoding vanillate demethylase. J. Bacteriol. 170 (1988) 4924-4930. [PMID: 3170489]

2. Priefert, H., Rabenhorst, J. and Steinbuchel, A. Molecular characterization of genes of Pseudomonas sp. strain HR199 involved in bioconversion of vanillin to protocatechuate. J. Bacteriol. 179 (1997) 2595-2607. [PMID: 9098058]

[EC created 2000 as EC, transferred 2003 to EC]

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