IUBMB Enzyme Nomenclature


Accepted name: dihydrosanguinarine 10-monooxygenase

Reaction: dihydrosanguinarine + [reduced NADPH—hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Other name(s): dihydrosanguinarine 10-hydroxylase

Systematic name: dihydrosanguinarine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)

Comments: A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. De-Eknamkul, W., Tanahashi, T. and Zenk, M.H. Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia. Phytochemistry 31 (1992) 2713-2717.

[EC created 1999 as EC, transferred 2018 to EC]

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