IUBMB Enzyme Nomenclature


Accepted name: N-methylcoclaurine 3'-monooxygenase

Reaction: (S)-N-methylcoclaurine + [reduced NADPH—hemoprotein reductase] + O2 = (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Other name(s): N-methylcoclaurine 3'-hydroxylase; CYP80B1 (gene name)

Systematic name: (S)-N-methylcoclaurine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)

Comments: A cytochrome P-450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant J. 13 (1998) 793-801. [PMID: 9681018]

[EC created 2001 as, transferred 2018 to EC]

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