IUBMB Enzyme Nomenclature


Accepted name: ent-cassa-12,15-diene 11-hydroxylase

Reaction: ent-cassa-12,15-diene + O2 + [reduced NADPH—hemoprotein reductase] = ent-11β-hydroxycassa-12,15-diene + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Other name(s): ent-cassadiene C11α-hydroxylase; CYP76M7

Systematic name: ent-cassa-12,15-diene,[reduced NADPH—hemoprotein reductase]:oxygen 11-oxidoreductase

Comments: A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the antifungal phytocassanes.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Swaminathan, S., Morrone, D., Wang, Q., Fulton, D.B. and Peters, R.J. CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice. Plant Cell 21 (2009) 3315-3325. [PMID: 19825834]

[EC created 2012 as EC, transferred 2018 to EC]

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