Reaction: 10-deoxysarpagine + [reduced NADPHhemoprotein reductase] + O2 = sarpagine + [oxidized NADPHhemoprotein reductase] + H2O
For diagram of reaction click here.
Other name(s): DOSH
Systematic name: 10-deoxysarpagine,[reduced NADPHhemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Comments: A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Yu, B., Ruppert, M. and Stöckigt, J. Deoxysarpagine hydroxylase a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia. Bioorg. Med. Chem. 10 (2002) 2479-2483. [PMID: 12057637]