IUBMB Enzyme Nomenclature


Accepted name: deoxysarpagine hydroxylase

Reaction: 10-deoxysarpagine + [reduced NADPH—hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH—hemoprotein reductase] + H2O

For diagram of reaction click here.

Other name(s): DOSH

Systematic name: 10-deoxysarpagine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)

Comments: A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yu, B., Ruppert, M. and Stöckigt, J. Deoxysarpagine hydroxylase — a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia. Bioorg. Med. Chem. 10 (2002) 2479-2483. [PMID: 12057637]

[EC created 2005 as EC, transferred 2018 to EC]

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